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The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervical cancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

《医学前沿（英文）》 2009年 第3卷 第4期   页码 447-451 doi: 10.1007/s11684-009-0082-x

摘要： This paper is aimed to examine if changes in platelet-derived growth factor (PDGF) expression at different stages of cervical cancer are related to the variation in blood vessel density (BVD) and lymphatic vessel density (LVD) to evaluate the relationship between PDGF expression and stages and metastasis of cervical cancer. Polymerase chain reaction (PCR) and RT-PCR were used to detect the expression levels of PDGF in 45 cervical cancer tissue samples (the experimental group). The samples were immunohistochemically stained with monoclonal antibodies D2-40 and CD34, and BVD and LVD were measured. The expressions of PDGF-A, -B, and- D were all higher in the experimental group than in the control group (<0.05); no significant difference was found in the expression of PDGF-C between the experimental group and the control group (>0.05). PDGF-A and -B expression was positively related with BVD and LVD (<0.01, R= 0.49, 0.527, 0.327, 0.68). The expression levels of PDGF-C and -D were not significantly related with BVD and LVD. At the early stage of cervical cancer, BVD and LVD were significantly higher than in the controls (<0.01). The BVD and LVD in tissues in the surrounding areas of cervical cancer were significantly higher than in tissues at cancer center, and LVD was related to lymph node metastasis (<0.001). BVD and LVD were not associated with the differentiation and pathological stages of cervical cancer. The expressions of PDGF-A, -B, and -D in cervical cancer were closely related with the clinical stages of cervical cancer. PDGF-A and -B were intimately associated with the lymph node metastasis and prognosis of cervical cancer.

关键词： cervical cancer     lymphatic vessel density     blood vessel density     platelet-derived growth factor    

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小口径血管的生物打印进展 Review

曹霞, Sushila Maharjan, Ramla Ashfaq, Jane Shin, Yu Shrike Zhang

《工程（英文）》 2021年 第7卷 第6期   页码 832-844 doi: 10.1016/j.eng.2020.03.019

摘要：

生物工程血管在再生医学和药物筛选等应用中的需求越来越大，但生物工程血管移植物的真正可用性仍然有限。三维（3D）生物打印技术为移植和再生提供了一种潜在的血管或血管化组织结构的制备方法。本文总结了不同血管的基本生物学特性，以及用于制备血管和血管化组织结构的3D生物打印方法和生物墨水设计，重点探讨了小口径血管。

关键词： 生物打印     小口径血管     生物墨水     血管生物工程    

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基于先验形状和局部统计的血管影像图像分割方法 Research Articles

Yun TIAN, Zi-feng LIU, Shi-feng ZHAO

《信息与电子工程前沿（英文）》 2019年 第20卷 第8期   页码 1099-1108 doi: 10.1631/FITEE.1800129

摘要： 快速准确地从医学图像中提取血管结构是许多临床医疗的基础。然而，大多数血管分割方法忽略了分割结果中孤立点和冗余点的存在。本文提出一种基于先验形状和局部统计的血管分割方法，能有效消除异常值并精确分割粗细血管。首先，定义了一种改进的血管滤波器，用于量化每个体素属于管状结构的可能性；其次，执行匹配和连接操作以获得血管掩模；最后，在血管掩模基础上实现基于局部统计的区域生长方法，得到较为完整的无外围值的血管树。与Frangi方法以及Yang方法在实际血管造影图像上的实验和比较，证明该方法在保持血管分支连通的同时，可以有效去除异常值。

关键词： 血管滤波器；邻域；血管分割；外围值    

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Bioaerosol: A Key Vessel between Environment and Health

《环境科学与工程前沿（英文）》 2021年 第15卷 第3期 doi: 10.1007/s11783-021-1422-6

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Non-invasive continuous blood pressure monitoring: a review of current applications

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 91-101 doi: 10.1007/s11684-013-0239-5

摘要：

Blood pressure monitoring has come a long way from the initial observations made by Reverend Hales in the 18th century. There are none that deny the importance of monitoring perioperative blood pressure; however, the limited ability of the current prevalent technology (oscillometric blood pressure monitoring) to offer continuous blood pressure measurements leaves room for improvement. Invasive monitoring is able to detect beat-to-beat blood pressure measurement, but the risks inherent to the procedure make it unsuitable for routine use except when this risk is outweighed by the benefits. This review focuses on the discoveries which have led up to the current blood pressure monitoring technologies, and especially the creation of those offering non-invasive but continuous blood pressure monitoring capabilities, including their methods of measurement and limitations.

关键词： non-invasive blood pressure monitoring     continuous blood pressure monitoring     invasive blood pressure monitoring     Riva-Rocci technique     oscillometric     Pe?áz technique     arterial tonometry     pulse transit time    

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Probabilistic model for vessel-bridge collisions in the Three Gorges Reservoir

Bo GENG , Hong WANG , Junjie WANG ,

《结构与土木工程前沿（英文）》 2009年 第3卷 第3期   页码 279-285 doi: 10.1007/s11709-009-0044-z

摘要： Based on a field observation on vessel transit path of three bridges over the Yangtze River in the Three Gorges Reservoir, and an analysis of the geometric probabilistic model of transiting vessels in collision probability calculation, the aberrancy angle and vessel velocity probabilistic model related with impact force, a probabilistic model is established and also verified by goodness-of-fit test. The vessel transit path distribution can be expressed by the normal distribution model. For the Three Gorges Reservoir, the mean and standard deviation adopt 0.2 and 0.1, respectively ( is the channel width). The aberrancy angle distribution of vessels accepts maximum I distribution model, and its distribution parameters can be taken as 0.314 and 4.354. The velocity distribution of up-bound and down-bound vessels can also be expressed by the normal distribution model.

关键词： vessel-bridge collision     probabilistic model     parameter statistics    

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Construction of the vessel-collateral theory and its guidance for prevention and treatment of vasculopathy

Yiling Wu

《医学前沿（英文）》 2011年 第5卷 第2期   页码 118-122 doi: 10.1007/s11684-011-0140-z

摘要： According to the self-discipline of traditional Chinese medicine, vessel-collateral theory was constructed systematically, which was important to improving prevention and treatment level of vasculopathy. The hypothesis of “homeostasis ( ), compensatory auto-adaptation ( ), regulation ( ) and equilibrium ( )” based on the “qi–yin-yang–five elements” coupled with the (nutrients)- (defense) theory, has become the core content of the vessel-collateral theory. Clinical and laboratory trials have been developed to further confirm the scientific connotations of the hypothesis, such as capsule, as the representative drugs of vessel collateral theory, showed good efficacy in protecting the vascular endothelium, stabilizing the vulnerable plaque and reducing the blood vessel spasm. “Sou, ti, shu, tong” was the characteristics of capsule in treating “microvascular damage” as the core mechanism of acute myocardial infarction, cerebral infarction and microvascular complications of diabetes. capsules in the treatment of arrhythmia have made integrated adjustment advantage. capsules have been made treating both manifestation and root cause of chronic heart failure. These research have improved prevention and treatment level of major vascular system diseases.

关键词： vessel-collateral theory     vasculopathy     prevention and treatment    

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Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

《医学前沿（英文）》 2008年 第2卷 第2期   页码 178-181 doi: 10.1007/s11684-008-0033-y

摘要： To study the relationship of the polymorphism of endothelial nitric oxide synthase (eNOS) gene and blood pressure, lipid profiles and blood glucose level. By using PCR-RFLP, the eNOS Glu298Asp gene polymorphism was detected in 184 patients with essential hypertension and 196 matched healthy individuals with normal blood pressure. Taking into account eNOS Glu298Asp polymorphisms, the relationship of blood pressure with triglycerides (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL) and blood glucose level was analyzed. The distribution of eNOS Glu298Asp polymorphism had no significant difference between different blood pressure groups and gender groups, but there was a significant difference between different age groups, diastolic blood pressure groups or BMI groups ( < 0.05). Asp/Asp genotype significantly increased the risk of hypertension in individuals with serum TC above 5.4 mmol/L ( = 0.03, = 2.65). eNOS Glu298Asp polymorphism and serum lipid could synergistically modulate the blood pressure. eNOS Asp/Asp genotype could significantly increase the risk of hypertension in individuals with serum TC over 5.4 mmol/L. eNOS Glu298Asp in combination with serum TC could be used to predict the risk of hypertension.
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White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

《医学前沿（英文）》 2019年 第13卷 第6期   页码 741-746 doi: 10.1007/s11684-017-0579-7

摘要： Hyperuricemia (HUA) is a risk factor for chronic kidney disease (CKD). The relationship between HUA and white blood cell (WBC) count remains unknown. A sampling survey for CKD was conducted in Sanlin community in 2012 and 2014. CKD was defined as proteinuria in at least the microalbuminuric stage or an estimated GFR of 60 mL/(min·1.73 m ). HUA was defined as serum uric acid>420 µmol/L in men and>360 µmol/L in women. This study included 1024 participants. The prevalence of HUA was 17.77%. Patients with HUA were more likely to have higher levels of WBC count, which was positively associated with HUA prevalence. This association was also observed in participants without CKD, diabetes mellitus, hyperlipidemia, or obesity. Multivariate logistic regression analysis showed that WBC count was independently associated with the risk for HUA in male and female participants. Compared with participants without HUA, inflammatory factors such as high-sensitivity C-reactive protein, tumor necrosis factor-α and interleukin 6 increased in participants with HUA. Hence, WBC count is positively associated with HUA, and this association is independent of conventional risk factors for CKD.

关键词： white blood cell count     hyperuricemia     chronic kidney disease     inflammation    

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gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

《化学科学与工程前沿（英文）》 2011年 第5卷 第3期   页码 392-400 doi: 10.1007/s11705-011-1202-0

摘要： In this paper, a scaffold, which mimics the morphology and mechanical properties of a native blood vessel is reported. The scaffold was prepared by sequential bi-layer electrospinning on a rotating mandrel-type collector. The tubular scaffolds (inner diameter 4 mm, length 3 cm) are composed of a polyurethane (PU) fibrous outer-layer and a gelatin-heparin fibrous inner-layer. They were fabricated by electrospinning technology, which enables control of the composition, structure, and mechanical properties of the scaffolds. The microstructure, fiber morphology and mechanical properties of the scaffolds were examined by means of scanning electron microscopy (SEM) and tensile tests. The PU/gelatin-heparin tubular scaffolds have a porous structure. The scaffolds achieved a breaking strength (3.7±0.13 MPa) and an elongation at break (110±8%) that are appropriate for artificial blood vessels. When the scaffolds were immersed in water for 1 h, the breaking strength decreased slightly to 2.2±0.3 MPa, but the elongation at break increased to 145±21%. In platelet adhesion tests the gelatin-heparin fibrous scaffolds showed a significant suppression of platelet adhesion. Heparin was released from the scaffolds at a fairly uniform rate during the period of 2 day to 9 day. The scaffolds are expected to mimic the complex matrix structure of native arteries, and to have good biocompatibility as an artificial blood vessel owing to the heparin release.

关键词： electrospinning     artificial blood vessels     scaffold     polyurethane     gelatin     nanofiber     hemocompatibility    

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Study of blood exposure-related mental health illness among clinical nurses

null

《医学前沿（英文）》 2017年 第11卷 第1期   页码 147-151 doi: 10.1007/s11684-016-0481-8

摘要：

Nurses are subjected to high amount of stress in the medical setting, and work-related stress often leads to mental problems. This study aims to investigate the mental health status of nurses exposed to blood through needlestick injuries. A total of 302 nurses working in the hospital of Guangdong, China, participated in this study. Out of the 302 nurses, 140 did not experience any needlestick injuries during the previous week, whereas 162 nurses experienced needlestick injuries. The General Health Questionnaire (GHQ)-28 Standardized Questionnaire, which uses physical, anxiety, social function, and depression subscales, was used in this study. No significant difference between nurses exposed to blood and nurses not exposed to blood was found in terms of gender, age, length of employment, and civil status (P>0.05). Results from the GHQ-28 Standardized Questionnaire showed that 75.9% (123/162) of nurses exposed to blood were suspected to suffer from mental disorders, whereas 40% (56/140) of nurses not exposed to blood were suspected to suffer from mental disorders. The mean mental health scores of nurses exposed to blood and those not exposed were 8.73±7.32 and 5.69±5.70, respectively. From these results, we can conclude that blood exposure from needlestick injuries leads to higher prevalence of depression, anxiety, and stress symptoms in nurses. This finding highlights the importance of providing efficient, adequate, and appropriate support services after nurses are exposed to blood from needlestick injuries.

关键词： blood exposure     needlestick injuries     mental health     nurses    

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Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

《医学前沿（英文）》 2011年 第5卷 第4期   页码 336-340 doi: 10.1007/s11684-011-0163-5

摘要： Endostatin, a 20 kDa C-terminal fragment of collagen XVIII, was first identified as a potent angiogenic inhibitor. The anti-angiogenic function of endostatin has been well documented during the past decade. Recently, several studies demonstrated that endostatin also inhibits tumor lymphangiogenesis and lymphatic metastasis. However, the exact mechanism that endostatin executes its anti-angiogenic and anti-lymphangiogenic functions remains elusive. In the current mini-review, we briefly summarize recent novel findings, including the functions of endostatin targeting not only angiogenesis but also lymphangiogenesis, and the underlying mechanism by which endostatin internalization regulates its biological functions.

关键词： endostatin     angiogenesis     lymphangiogenesis     nystatin     internalization     tumor    

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Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

《能源前沿（英文）》 2007年 第1卷 第1期   页码 120-124 doi: 10.1007/s11708-007-0014-x

摘要： Freeze-drying of human red blood cells has a potential important application for blood transfusion. The aim of this study was to investigate the effects of intracellular trehalose on the survival of red blood cells after freeze-drying and rehydration. Fresh red blood cells were incubated in trehalose solutions of various concentrations at 37vH for 7 h following freeze-drying. Polyvinylpyrrolidone, Trehalose, sodium citrate, and human serum albumin were used as extracellular protective agents for the freeze-drying of red blood cells. The results indicated that the intracellular trehalose concentration was increased with increasing concentration of extracellular trehalose solution, and the maximum concentration of intracellular trehalose reached 35 mmol/L. The viability of freeze-dried red blood cells increased with the increment of intracellular trehalose concentration.
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Cell carrier function of hollow-fiber membrane in rotating wall vessel bioreactor

SONG Kedong, LIU Tianqing, ZHAO Hu, LI Xiangqin, MA Xuehu, CUI Zhanfeng

《化学科学与工程前沿（英文）》 2008年 第2卷 第1期   页码 34-39 doi: 10.1007/s11705-008-0022-3

摘要： Large-scale expansion of the osteoblasts of a Sprague-Dawley (SD) rat was studied in a rotating wall hollow-fiber membrane bioreactor (RWHMB) by using hollow-fiber membrane as the carrier. For the sake of contrast, cells were also expanded in a T-flask using a hollow-fiber membrane as carrier and in a rotating wall vessel bioreactor (RWVB) using a microcarrier. During the culture period, the cells were sampled every 12 h, and after 5 days, the cells were harvested and evaluated with scanning electron microscopy (SEM), hematoxylin-eosin (HE) staining and alkaline phosphatase (ALP) staining. Moreover, von-Kossa staining and Alizarin Red S staining were carried out for mineralized nodules formation. The results show that in RWHMB, the cells present better morphology and vitality and secrete much more extracellular matrix. It is concluded that the RWHMB combines the advantages of the rotating wall vessel and hollow-fiber membrane bioreactors. The hydrodynamic stimulation within it accelerates the metabolism of the osteoblast and mass transfer, which is propitious to cell differentiation and proliferation.

关键词： RWHMB     microcarrier     hematoxylin-eosin     von-Kossa staining     propitious    

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我国人群血脂水平现状及其对策

陈灏珠,金雪娟

《中国工程科学》 2002年 第4卷 第11期   页码 1-6

摘要：

回顾分析50年来我国健康人群血脂水平的变化，结果显示血总胆固醇（TC）、甘油三酯（TG）和低密度脂蛋白胆固醇（LDL-C）随年龄而增高,50岁以前男女间无差别,50岁以后女性高于男性,城市居民高于农村居民；高密度脂蛋白胆固醇（HDL-C）随年龄的变化不明显,男性低于女性；血TC、TG和LDL-C随年代而增高,20世纪90年代末达最高峰,而HDL-C则下降；血TC高于正常者（＞200～220 mg/dL）男性占17.8 %～54.9 %,女性占14.9 %～53.4 %，也随年代而增多；血脂水平的变化与饮食结构转变为低碳水化合物、高脂肪、高胆固醇有关。对策:恢复健康的饮食习惯,摄取平衡饮食；建立良好生活习惯，减少其他心血管病危险因素,特别建议进行体育锻炼；已有血脂异常,经饮食调节和体育锻炼3个月以上仍未见好转者,宜接受调脂药物治疗。

关键词： 血脂     流行病学     预防    

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标题 作者 时间 类型 操作

The relationship between platelet-derived growth factor expression and angiogenesis/lymphangiogenesis in cervical cancer

Guocheng LIU MD, Shouhua YANG MD, Zehua WANG MD,

期刊论文

小口径血管的生物打印进展

曹霞, Sushila Maharjan, Ramla Ashfaq, Jane Shin, Yu Shrike Zhang

期刊论文

基于先验形状和局部统计的血管影像图像分割方法

Yun TIAN, Zi-feng LIU, Shi-feng ZHAO

期刊论文

Bioaerosol: A Key Vessel between Environment and Health

期刊论文

Non-invasive continuous blood pressure monitoring: a review of current applications

null

期刊论文

Probabilistic model for vessel-bridge collisions in the Three Gorges Reservoir

Bo GENG , Hong WANG , Junjie WANG ,

期刊论文

Construction of the vessel-collateral theory and its guidance for prevention and treatment of vasculopathy

Yiling Wu

期刊论文

Relationship of endothelial nitric oxide synthase gene polymorphism with blood pressure, lipid profileand blood glucose level

TANG Zhongzhi, LI Junyao, YANG Jianhong

期刊论文

White blood cell count and the incidence of hyperuricemia: insights from a community-based study

Jian Liu, Pingyan Shen, Xiaobo Ma, Xialian Yu, Liyan Ni, Xu Hao, Weiming Wang, Nan Chen

期刊论文

gelatin-heparin nanofibrous scaffolds formed by a bi-layer electrospinning technique as potential artificial blood

Heyun WANG, Yakai FENG, Marc BEHL, Andreas LENDLEIN, Haiyang ZHAO, Ruofang XIAO, Jian LU, Li ZHANG, Jintang GUO

期刊论文

Study of blood exposure-related mental health illness among clinical nurses

null

期刊论文

Endostatin specifically targets both tumor blood vessels and lymphatic vessels

Wei Zhuo, Yang Chen, Xiaomin Song, Yongzhang Luo

期刊论文

Intracellular trehalose improves the survival of human red blood cells by freeze-drying

HE Hui, LIU Baolin, HUA Zezhao, LI Chuan, WU Zhengzheng

期刊论文

Cell carrier function of hollow-fiber membrane in rotating wall vessel bioreactor

SONG Kedong, LIU Tianqing, ZHAO Hu, LI Xiangqin, MA Xuehu, CUI Zhanfeng

期刊论文

我国人群血脂水平现状及其对策

陈灏珠,金雪娟

期刊论文